Hydroxy Camptothecine|99%|abs817263-爱必信(上海)生物科技有限公司

Hydroxy Camptothecine

参考价：¥294

供货周期：

一周

品牌：

爱必信

规格：

99%

货号：

abs817263

CAS号：

64439-81-2

产品详情

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抑制剂描述：

产品名称：Hydroxy Camptothecine

产品别名：见爱必信官网

英文别名：Hydroxy Camptothecine

靶点：Topoisomerase

CAS：64439-81-2

纯度：99%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.

溶解性：Soluble in DMSO

体外研究：

10-HCPT has an inhibitory effect on phosphorylation of histone H1 and H3 in murine hepatoma cells and also exhibits a differentiation inducing effect in human HepG2 cells. 10-HCPT inhibits the cell growth, reduces the cell viability and disturbs the cell cycle distribution of human colon cancer cell line Colo 205. It induces cell cycle arrest in the G2/M phase.

体内研究：10-HCPT can be safely orally administered and, alternatively, a low-dose long-term treatment. Prolonged elimination of HCPT in vivo may have a significant impact on its therapeutic effects. HCPT is metabolized to its carboxylate form and glucuronides. Dose-dependent toxicity is observed with i.v. administration of HCPT.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs817263	Hydroxy Camptothecine	5mg	294.00	立即咨询
abs817263	Hydroxy Camptothecine	10mg	389.00	立即咨询
abs817263	Hydroxy Camptothecine	25mg	767.00	立即咨询
abs817263	Hydroxy Camptothecine	50mg	1229.00	立即咨询

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