Mitoxantrone dihydrochloride|>99%|abs814423-爱必信(上海)生物科技有限公司

Mitoxantrone dihydrochloride

参考价：¥441

供货周期：

一周

品牌：

爱必信

规格：

>99%

货号：

abs814423

CAS号：

70476-82-3

产品详情

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

抑制剂描述：

产品名称：Mitoxantrone dihydrochloride

产品别名：见爱必信官网

英文别名：Mitoxantrone dihydrochloride

靶点：Topoisomerase

CAS：70476-82-3

纯度：>99%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Mitoxantrone Hydrochloride is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor.

溶解性：DMSO : 38.8 mg/mL (75 mM)
water : 2.6 mg/mL (5 mM)

体外研究：

Mitoxantrone induces DNA fragmentation and the proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), a marker of the activation of caspases, in all the patients studied, demonstrating that the cytotoxic effect of mitoxantrone is due to induction of apoptosis. Mitoxantrone activates NFkappaB and stimulates IkappaBalpha degradation in the promyelocytic leukemia cell line HL60 but not in the variant cells, HL60/MX2 cells, which lack the beta isoform of topoisomerase II and express a truncated alpha isoform that results in an altered subcellular distribution. Mitoxantrone inhibits proliferation of activated PBMCs, B lymphocytes, or antigen-specific T-cell lines (TCLs) stimulated on antigen-presenting cells (APCs) in a dose-dependent manner. Mitoxantrone induces apoptosis of PBMCs, monocytes and DCs at low concentrations, whereas higher doses causes cell lysis.

体内研究：Mitoxantrone transiently decreases the growth rate of HID xenografts in mice but does not affect that of PAC120 xenografts. Mitoxantrone results in the severity of the cardiac lesions and the nephropathy and the intestinal toxicity in spontaneously hypertensive rats. Mitoxantrone and iron(III) form a strong 2:1 complex, in which mitoxantrone may be acting as a tridentate ligand.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs814423	Mitoxantrone dihydrochloride	25mg	441.00	立即咨询
abs814423	Mitoxantrone dihydrochloride	50mg	545.00	立即咨询
abs814423	Mitoxantrone dihydrochloride	100mg	958.00	立即咨询

产品更多信息请进入爱必信网站咨询