供货周期: | 一周 |
品牌: | 爱必信 |
规格: | |
货号: | abs820459 |
CAS号: | 125974-72-3 |
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抑制剂描述: 产品名称:Intoplicine 产品别名:见爱必信官网 英文别名:Intoplicine 靶点:Topoisomerase CAS:125974-72-3 纯度: 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder) 描述:Intoplicine is a DNA topoisomerase I and II inhibitor. 溶解性:DMSO* 体外研究: Activity of Intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. Intoplicine (RP60475) is the most active analogue evaluated in the 7H-benzo[e]-pyrido-[4,3-b]-indole series of antineoplastic compounds. Intoplicine exerts its activity through inhibition of DNA topoisomerase I and II. Intoplicine is found to unwind DNA and to inhibit purified calf thymus topoisomerase II via a stabilization of the ternary cleavable complex. 体内研究:Activity of Intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. Intoplicine (RP60475) is the most active analogue evaluated in the 7H-benzo[e]-pyrido-[4,3-b]-indole series of antineoplastic compounds. Intoplicine exerts its activity through inhibition of DNA topoisomerase I and II. Intoplicine is found to unwind DNA and to inhibit purified calf thymus topoisomerase II via a stabilization of the ternary cleavable complex.
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