Dxd|98%|abs820987-爱必信(上海)生物科技有限公司

Dxd

参考价：¥8190

供货周期：

一周

品牌：

爱必信

规格：

98%

货号：

abs820987

CAS号：

1599440-33-1

产品详情

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抑制剂描述：

产品名称：Dxd

产品别名：见爱必信官网

英文别名：Dxd

靶点：Topoisomerase;ADC Cytotoxin

CAS：1599440-33-1

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).

溶解性：

体外研究：

Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). Dxd is cytotoxic to human cancer cell lines of KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 with IC50s of 1.43 nM-4.07 nM, but the control IgG-ADC (Dxd is the payload) shows no inhibition on the four cell lines (with HER2 expression). DS-8201a (Dxd is the payload) displays significant suppression on the HER2-positive KPL-4, NCI-N87, and SK-BR-3 cell lines, with IC50 values of 26.8, 25.4, and 6.7 ng/mL, respectively, but with no such inhibition on MDA-MB-468 (IC50, >10,000 ng/mL).

体内研究：Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). Dxd is cytotoxic to human cancer cell lines of KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 with IC50s of 1.43 nM-4.07 nM, but the control IgG-ADC (Dxd is the payload) shows no inhibition on the four cell lines (with HER2 expression). DS-8201a (Dxd is the payload) displays significant suppression on the HER2-positive KPL-4, NCI-N87, and SK-BR-3 cell lines, with IC50 values of 26.8, 25.4, and 6.7 ng/mL, respectively, but with no such inhibition on MDA-MB-468 (IC50, >10,000 ng/mL).

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs820987	Dxd	1mg	8190.00	立即咨询
abs820987	Dxd	5mg	16380.00	立即咨询

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