| 供货周期： | 一周 |
| 品牌： | 爱必信 |
| 规格： | 98% |
| 货号： | abs814701 |
| CAS号： | 6147-11-1 |
| 公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!
抑制剂描述： 产品名称：Mangostin 产品别名：见爱必信官网 英文别名：Mangostin 靶点：Xanthones CAS：6147-11-1 纯度：98% 外观：见爱必信官网 保存方法：Store at -20° C 描述： Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree. 溶解性：DMSO : ≥ 37 mg/mL (90.14 mM) 体外研究： Alpha-mangostin exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. Alpha-mangostin competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. The structure–relationship study reveals that alpha-mangostin exhibits the strongest core inhibitor structure. Alpha-mangostin selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells. Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Alpha-mangostin also increases the levels of Bax (pro-apoptotic), cleaved caspase-3, cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP). Alpha-mangostin significantly inhibits light-induced degeneration of photoreceptors and 200 μM Water2-induced apoptosis of RPE cells. 200 μM Water2-induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-mangostin. 体内研究：Alpha-mangostin reduces risk of liver fibrosis through the decrease in p53 expression as compared to the TAA_DMSO treatment. The serum levels of the liver enzymes AST and ALT after treatment with α-mangostin decrease as compared to DMSO alone.
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