供货周期: | 一周 |
品牌: | 爱必信 |
规格: | ≥98% |
货号: | abs810216 |
CAS号: | 305834-79-1 |
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抑制剂描述: 产品名称:SC-79 产品别名:见爱必信官网 英文别名:SC-79 靶点:Akt CAS:305834-79-1 纯度:≥98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: SC-79 is an activator of Akt; binds to the pleckstrin homology domain of Akt. 溶解性:DMSO :36.5 mg/mL (100 mM) 体外研究: SC79 suppresses PHAKTM-GFP plasma membrane translocation, and enhances phosphorylation of all three Akt isoforms in HEK293, HeLa, HL60, NB4, and HsSulton (B cells) cells. SC79 reduces neuronal excitotoxicity and prevents stroke-induced neuronal death. SC79 restores proliferation of BRAT1 knockdown cells, and reduces the production of superoxide in mitochondria of MitoSox positive cells. 体内研究:In the permanent focal cerebral ischemia mouse model, SC79 (0.04 mg/g, i.p.) enables the cytosolic activation of Akt, and recapitulates the primary cellular function of Akt signaling, resulting in augmented neuronal survival.
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