A-674563|≥98%|abs812083-爱必信(上海)生物科技有限公司

A-674563

参考价：¥1213

供货周期：

一周

品牌：

爱必信

规格：

≥98%

货号：

abs812083

CAS号：

552325-73-2

产品详情

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

抑制剂描述：

产品名称：A-674563

产品别名：见爱必信官网

英文别名：A-674563

靶点：Akt

CAS：552325-73-2

纯度：≥98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

A-674563 is a potent and selective Akt1 inhibitor with a Ki of 11 nM.

溶解性：DMSO ：72 mg/mL (200.87 mM)
Water ：72 mg/mL (200.87 mM)
Ethanol ：18 mg/mL (50.21 mM)

体外研究：

A-674563 is achieved from A-443654 by replacing the indole with a phenyl moiety and getting oral activity. A-674563 slows proliferation of tumor cells with EC50 of 0.4 μM. A-674563 does not inhibit Akt phosphorylation per se, but blocks the phosphorylation of Akt downstream targets in a dose-dependent manner. A-674563 induced Akt blockade results in decreased STS cell downstream target phosphorylation and tumor cell growth inhibiton. A-674563 induces G2 cell cycle arrest and apoptosis in STS cells.

体内研究：20 mg/kg A-674563 increases plasma insulin in an oral glucose tolerance test. A-674563 shows no significant monotherapy tumor inhibitory activity; the efficacy of the combination therapy is significantly improved compared to paclitaxel monotherapy. A674563-treated (20 mg/kg/bid, p.o.) mice exhibits slower tumor growth and more than 50% decrease in the tumor volume at the termination of the study compared with that in control group. A-674563 is identified to have drastically improved PK profile with oral bioavailability of 67% in mouse, but is 70-fold less active than A-443654.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs812083	A-674563	2mg	1213.00	立即咨询
abs812083	A-674563	5mg	2097.00	立即咨询
abs812083	A-674563	10mg	3275.00	立即咨询

产品更多信息请进入爱必信网站咨询