供货周期: | 一周 |
品牌: | 爱必信 |
规格: | |
货号: | abs820506 |
CAS号: | 1292821-90-9 |
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抑制剂描述: 产品名称:K-80003 产品别名:见爱必信官网 英文别名:K-80003 靶点:Akt CAS:1292821-90-9 纯度: 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder) 描述:K-80003 is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth. 溶解性:DMSO* 体外研究: When MCF-7 cells are cotreated with K-80003, TNFα-induced colocalization of tRXRα with p85α in the cytoplasm is inhibited, resulting in tRXRα nuclear localization. Western blotting shows that K-80003-stabilized tetrameric form of tRXRα is found exclusively in the nuclear fraction, while tRXRα monomer is distributed both in the nuclear and cytoplasmic fractions. 体内研究:When MCF-7 cells are cotreated with K-80003, TNFα-induced colocalization of tRXRα with p85α in the cytoplasm is inhibited, resulting in tRXRα nuclear localization. Western blotting shows that K-80003-stabilized tetrameric form of tRXRα is found exclusively in the nuclear fraction, while tRXRα monomer is distributed both in the nuclear and cytoplasmic fractions.
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