供货周期: | 一周 |
品牌: | 爱必信 |
规格: | ≥95% |
货号: | abs816093 |
CAS号: | 1256493-34-1 |
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抑制剂描述: 产品名称:Dyngo-4a 产品别名:见爱必信官网 英文别名:Dyngo-4a 靶点:Dynamin CAS:1256493-34-1 纯度:≥95% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: Dyngo-4a is a potent <b>dynamin</b> inhibitor with <b>IC50</b> of 0.38 μM, 1.1?μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively. 溶解性:DMSO :67 mg/mL (198.04 mM) 体外研究: Dyngo-4a inhibits dynamin-dependent endocytosis of transferrin in multiple cell types with IC?? of 5.7 μM, and reduces synaptic vesicle endocytosis and activity-dependent bulk endocytosis in cultured neurons and synaptosomes. In motor nerve terminals and cultured hippocampal neurons, Dyngo-4a blocks Alexa Fluor 488-BoNT/A-Hc internalization. In Drosophila S2R+ cells, Dyngo-4a causes a decrease in the level of Armadillo/β-catenin. 体内研究:
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