Lifitegrast(SAR 1118)|98%|abs810103-爱必信(上海)生物科技有限公司

Lifitegrast(SAR 1118)

参考价：¥947

供货周期：

一周

品牌：

爱必信

规格：

98%

货号：

abs810103

CAS号：

1025967-78-5

产品详情

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抑制剂描述：

产品名称：Lifitegrast(SAR 1118)

产品别名：见爱必信官网

英文别名：Lifitegrast(SAR 1118)

靶点：Integrin

CAS：1025967-78-5

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

SAR 1118 is a potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonist for treating dry eye.

溶解性：DMSO: ≥ 29 mg/mL

体外研究：

Lifitegrast inhibits release of cytokines, interferon d, tumor necrosis factor alpha (TNF-α), and other interleukins (ILs). It is a novel integrin antagonist which prevents LFA-1/ICAM-1 interaction preventing T-cell activation/recruitment and release of inflammatory mediators, thereby decreasing the inflammatory responses in DED.

体内研究：In vivo study of lifitegrast as radiolabeled drops in rats demonstrated that it was rapidly distributed in ocular and periocular tissues, cleared by normal tear drainage, and was devoid of systemic side effects. A similar dose tolerability study of lifitegrast in dogs suffering from keratoconjunctivitis sicca proved its efficacy and safety. Lifitegrast is found to be a highly potent drug in various clinical trials as it alleviates both the signs and symptoms of DED, which showed rapid onset of action and good therapeutic efficacy as ophthalmic drops. It protected the corneal surfaces and was well tolerated locally as well as systemically.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs810103	Lifitegrast(SAR 1118)	5mg	947.00	立即咨询
abs810103	Lifitegrast(SAR 1118)	10mg	1594.00	立即咨询
abs810103	Lifitegrast(SAR 1118)	50mg	5717.00	立即咨询
abs810103	Lifitegrast(SAR 1118)	100mg	7319.00	立即咨询

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