Tirofiban|>98%|abs810712-爱必信(上海)生物科技有限公司

Tirofiban

参考价：¥1109

供货周期：

一周

品牌：

爱必信

规格：

>98%

货号：

abs810712

CAS号：

144494-65-5

产品详情

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抑制剂描述：

产品名称：Tirofiban

产品别名：见爱必信官网

英文别名：Tirofiban

靶点：Integrin

CAS：144494-65-5

纯度：>98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.

描述：

Tirofiban(L700462;MK383) is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist.

溶解性：DMSO 0.005 mg/mL (0.01 mM)

体外研究：

Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitronectin receptor. It inhibits platelet aggregation of gel-filtered platelets induced by 10 μM ADP with IC50 of 9 nM, but the IC50 for inhibition of human umbilical vein adhesion to vitronectin, which depends on ɑvβ3 vitronectin receptors, is 62 μmol/L.

体内研究：Tirofiban (10 to 500 mg/kg or 360-min continuous i.v. infusions of 1 to 10 micrograms/kg/min) inhibits platelet aggregation responses to ADP and collagen in canine models. When administered to humans at 0.15μg/kg/min for 4 h, Tirofiban produced a 2.5-fold increase in bleeding time and 97% inhibition of ADP-induced platelet aggregation.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs810712	Tirofiban	5mg	1109.00	立即咨询
abs810712	Tirofiban	50mg	4657.00	立即咨询

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