Tirofiban hydrochloride monohydrate|＞98%|abs817559-爱必信(上海)生物科技有限公司

Tirofiban hydrochloride monohydrate

参考价：¥358

供货周期：

一周

品牌：

爱必信

规格：

＞98%

货号：

abs817559

CAS号：

150915-40-5

产品详情

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抑制剂描述：

产品名称：Tirofiban hydrochloride monohydrate

产品别名：见爱必信官网

英文别名：Tirofiban hydrochloride monohydrate

靶点：Integrin

CAS：150915-40-5

纯度：＞98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist

溶解性：DMSO : 12 mg/mL (24.24 mM; Need ultrasonic and warming)

体外研究：

Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitronectin receptor. It inhibits platelet aggregation of gel-filtered platelets induced by 10 μM ADP with IC50 of 9 nM, but the IC50 for inhibition of human umbilical vein adhesion to vitronectin, which depends on ɑvβ3 vitronectin receptors, is 62 μmol/L.

体内研究：Tirofiban Hydrochloride (10 to 500 mg/kg or 360-min continuous i.v. infusions of 1 to 10 micrograms/kg/min) inhibits platelet aggregation responses to ADP and collagen in canine models. When administered to humans at 0.15μg/kg/min for 4 h, Tirofiban produced a 2.5-fold increase in bleeding time and 97% inhibition of ADP-induced platelet aggregation.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs817559	Tirofiban hydrochloride monohydrate	5mg	358.00	立即咨询
abs817559	Tirofiban hydrochloride monohydrate	10mg	541.00	立即咨询
abs817559	Tirofiban hydrochloride monohydrate	25mg	966.00	立即咨询
abs817559	Tirofiban hydrochloride monohydrate	100mg	3537.00	立即咨询

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