供货周期: | 一周 |
品牌: | 爱必信 |
规格: | >98% |
货号: | abs817559 |
CAS号: | 150915-40-5 |
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抑制剂描述: 产品名称:Tirofiban hydrochloride monohydrate 产品别名:见爱必信官网 英文别名:Tirofiban hydrochloride monohydrate 靶点:Integrin CAS:150915-40-5 纯度:>98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist 溶解性:DMSO : 12 mg/mL (24.24 mM; Need ultrasonic and warming) 体外研究: Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitronectin receptor. It inhibits platelet aggregation of gel-filtered platelets induced by 10 μM ADP with IC50 of 9 nM, but the IC50 for inhibition of human umbilical vein adhesion to vitronectin, which depends on ɑvβ3 vitronectin receptors, is 62 μmol/L. 体内研究:Tirofiban Hydrochloride (10 to 500 mg/kg or 360-min continuous i.v. infusions of 1 to 10 micrograms/kg/min) inhibits platelet aggregation responses to ADP and collagen in canine models. When administered to humans at 0.15μg/kg/min for 4 h, Tirofiban produced a 2.5-fold increase in bleeding time and 97% inhibition of ADP-induced platelet aggregation.
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