供货周期: | 一周 |
品牌: | 爱必信 |
规格: | ≥98% |
货号: | abs816152 |
CAS号: | 161552-03-0(freebase) |
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抑制剂描述: 产品名称:Cyclo (-RGDfK) TFA 产品别名:见爱必信官网 英文别名:Cyclo (-RGDfK) TFA 靶点:Integrin CAS:161552-03-0(freebase) 纯度:≥98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: Cyclo (-RGDfK) is a potent and selective <b>αvβ3 integrin</b> inhibitor. 溶解性:Water :100 mg/mL (139.34 mM) 体外研究: The constant of affinity (KD) of Cyclo (-RGDfK-) for purified integrin is 41.70 nM. Cyclo (-RGDfK) is reacting with HEK293(β3) cells moderately. Cyclo(-RGDfK-) modified micelles shows strong affinity to T-24 cells and strong inhibitory effect on the proliferation of T-24 cells. 体内研究:In athymic mice bearing α(v)β(3)-integrin-positive C6 gliomas, Cyclo (-RGDfK-) modification induces less tumor progression, less tumor metabolic activity, fewer intratumoral vessels.
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