| 供货周期： | 现货 |
| 品牌： | 爱必信 |
| 型号： | ＞98% |
| 货号： | abs817944 |
| CAS号： | 22862-76-6 |
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抑制剂描述：
产品名称：Anisomycin
产品别名：茴香霉素
英文别名：Anisomycin
靶点：JNK
CAS：22862-76-6
纯度：＞98%
外观：见爱必信官网
保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.
描述：
Anisomycin是一种吡咯烷抗生素, 抑制蛋白质合成, 也是有效的SAPKs/JNKs激活剂。
溶解性：DMSO : 26.5 mg/mL (100 mM)
Ethanol : 13.3 mg/mL (50 mM)
体外研究：
Anisomycin (3 μM) decreases protein synthesis in MDA16 and MDA-MB-468 cells, and reduces colony formation by MDA-MB-468 cells. Anisomycin causes an increase in the number of apoptotic cells in MDA-MB-468 cultures, but not in MDA16 cultures. Anisomycin actives JNK phosphorylation in MDA-MB-468 cells. In U251 and U87 cells, anisomycin (0.01-8 μM) inhibits the cell growth in time- and concentration-dependent manners with the IC50 (48 h) values of 0.233 and 0.192 μmol/L, respectively. Anisomycin (4 μM) causes 21.5% and 25.3% of apoptosis proportion in U251 and U87 cells, respectively, and activates p38 MAPK and JNK, while inactivated ERK1/2. Anisomycin (4 μM) reduces the level of PP2A/C subunit in a time-dependent manner in U251 and U87 cells. Anisomycin inhibits EAC cell proliferation in concentration-dependent manner.
体内研究：Peritumoral administration of anisomycin (5 mg/kg) significantly suppresses Ehrlich ascites carcinoma (EAC) growth resulting in the survival of approximately 60% of the mice 90 days after EAC inoculation.
产品信息订购：
| 产品货号 | 产品名称 | 规格 | 价格 | 大包装及货期 |
| abs817944 | Anisomycin | 10mg | 526.00 | 立即咨询 |
| abs817944 | Anisomycin | 50mg | 1016.00 | 立即咨询 |
| abs817944 | Anisomycin | 100mg | 1802.00 | 立即咨询 |
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