供货周期: | 一周 |
品牌: | 爱必信 |
规格: | 98% |
货号: | abs819574 |
CAS号: | 666837-93-0 |
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抑制剂描述: 产品名称:SU-9516 产品别名:见爱必信官网 英文别名:SU-9516 靶点:CDK CAS:666837-93-0 纯度:98% 外观:见爱必信官网 保存方法:Store at -20° C 描述: SU-9516 is a 3-substituted indolinone compound displaying anti-proliferative and proapoptotic properties in tumor cells. SU-9516 displays activity as a selectively potent ATP-competitive inhibitor of CDKs. It also shows no significant effect (IC50 >10 μM) on the activities of PKC, p38, PDGFRβ, or EGFR. SU-9516 has an Inhibitory effect on proliferation of growth-factor stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F. SU-9516 is an inhibitor of Cdc2, Cdk2 and Cdk4. 溶解性:Soluble in DMSO (10 mg/ml), and ethanol (20 mM). Insoluble in water. 体外研究: 体内研究:
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