Rifaximin|≥99%|abs811892-爱必信(上海)生物科技有限公司

Rifaximin

参考价：¥525

供货周期：

一周

品牌：

爱必信

规格：

≥99%

货号：

abs811892

CAS号：

80621-81-4

产品详情

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抑制剂描述：

产品名称：Rifaximin

产品别名：见爱必信官网

英文别名：Rifaximin

靶点：DNA/RNA Synthesis

CAS：80621-81-4

纯度：≥99%

外观：见爱必信官网

保存方法：Store at -20°C

描述：

Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting bacterial RNA synthesis and bacterial cell growth.

溶解性：DMSO : 44 mg/mL (56 mM)
Ethanol : 3 mg/mL (3.81 mM)

体外研究：

Rifaximin (50 μM) reduces changes in the production of proinflammatory factors caused by LPS stimulation in IEC, such as TNF-α, IL-8, Rantes and PGE2 in normal intestinal epithelial cells. Rifaximin inhibits the LPS-induced cytokine and chemokine expression by suppressing NF-κB DNA-binding activity. Rifaximin (100 μM) effectively decreases the expression of TNFα, IL-8, MIP-3α and Rantes induced by LPS stimulation (100 μg/mL). Rifaximin binds the β subunit of the bacterial DNA-dependent RNA polymerase, inhibiting the initiation of chain formation in RNA synthesis. Rifaximin has a lower MIC against gram-positive bacteria, with an MIC90 at dosages ranging from 0.01 μg/mL to 0.5 μg/mL. Rifaximin has broad-spectrum activity against aerobic and anaerobic gram-positive and gram-negative microorganisms.

体内研究：Rifaximin is highly concentrated in the intestinal tract compared with rifampicin. Rifaximin treatment results in significant induction of PXR target genes in the intestine of hPXR mice, but not in wild-type and Pxr-null mice. Rifaximin-mediated activation of human PXR, but not the other xenobiotic nuclear receptors constitutive androstane receptor, peroxisome proliferator-activated receptor (PPAR)alpha, PPARgamma, and farnesoid X receptor. Rifaximin could lead to PXR-dependent hepatocellular fatty degeneration as a result of activation of genes involved in lipid uptake, thus indicating a potential adverse effect of rifaximin on liver function after long-term exposure.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs811892	Rifaximin	200mg	525.00	立即咨询
abs811892	Rifaximin	500mg	601.00	立即咨询
abs811892	Rifaximin	1g	966.00	立即咨询

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