供货周期: | 一周 |
品牌: | 爱必信 |
规格: | ≥98% |
货号: | abs812943 |
CAS号: | 989-51-5 |
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抑制剂描述: 产品名称:Epigallocatechin Gallate 产品别名:见爱必信官网 英文别名:Epigallocatechin Gallate 靶点:Telomerase CAS:989-51-5 纯度:≥98% 外观:见爱必信官网 保存方法:Store at -20°C 描述: Epigallocatechol Gallate(EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. 溶解性:Ethanol :45.8 mg/mL (100 mM) 体外研究: (-)-Epigallocatechin Gallate (EGCG) inhibits activation EGFR, HER2 and HER3 in the SW837 human colon cancer cell line. (-)-Epigallocatechin Gallate (10 μM) also inhibits cell growth, suppresses activation of EGFR, HER2, and HER3, and causes decrease in the levels of COX-2 and Bcl-xL proteins, and apoptosis after treatment for 96 h. (-)-Epigallocatechin Gallate (0-35 μg/mL) inhibits the proliferation of colorectal cancer cells. (-)-Epigallocatechin Gallate (35 μg/mL) induces apoptosis of colorectal cancer cells. (-)-Epigallocatechin Gallate (EGCG; 50, 75 and 100 μM) dose-dependently inhibits the growth of HepG2 cells, and induces apoptosis in HepG2 cells. 体内研究:(-)-Epigallocatechin Gallate (5, 10, and 20 mg/kg, p.o.) inhibits the growth of orthotopic colorectal cancer cells in mice.
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