供货周期: | 7天 |
品牌: | 爱必信 |
货号: | abs818823 |
CAS号: | 1065506-69-5 |
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抑制剂描述: 产品名称:Dafadine-A 产品别名:见爱必信官网 英文别名:Dafadine-A 靶点:P450 CAS:1065506-69-5 纯度: 外观:见爱必信官网 保存方法: 描述:Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1). IC50 value:Target: DAF-9(CYP27A1) inhibitorThe DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematodeCaenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals. 溶解性:10 mM in DMSO 体外研究: 体内研究:
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