供货周期: | 7天 |
品牌: | 爱必信 |
型号: | >98% |
货号: | abs810193 |
CAS号: | 667463-85-6 |
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抑制剂描述: 产品名称:BIO-Acetoxime 产品别名:见爱必信官网 英文别名:BIO-Acetoxime 靶点:GSK-3 CAS:667463-85-6 纯度:>98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: BIO-Acetoxime is an analog of the GSK3 inhibitor 6-bromoindirubin-3’-oxime, or BIO 溶解性:DMSO 19 mg/mL warmed (47.71 mM) 体外研究: In human oral epithelial cells, BIO-acetoxime suppresses viral gene expression and protects oral epithelial cells from HSV-1 infection. In SY5Y-MYCN cells, BIO-acetoxime strongly reduces c-MYC expression and p-SMAD3 levels. BIO-acetoxime also decreases cell viability of KCN, KCNR, SY5Y, Kelly, and IMR32 cells by mediating apoptosis. In HEK 293T cells, BIO-acetoxime is also found to reduce antiviral innate immunity downstream of IRF3 activation by inhibition of GSK3α/β activities. 体内研究:
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