供货周期: | 7天 |
品牌: | 爱必信 |
货号: | abs820897 |
CAS号: | 152317-89-0 |
公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!
抑制剂描述: 产品名称:Alniditan 产品别名:见爱必信官网 英文别名:Alniditan 靶点:5-HT Receptor CAS:152317-89-0 纯度: 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder) 描述:Alniditan is a potent 5-HT1B/1D receptors agonist, with IC50 of 1.7 and 1.3 nM in HEK?293 cells, and pKi value of 8.96 and 9.40 for 5-HT1B/1D receptors, respectively. 溶解性:DMSO* 体外研究: In vitro, alniditan exhibits little vasoconstrictive effects on the rat basilar artery, although at a very high concentration 1 mM, alniditan causes intensive constriction, most likely through a mechanism independent from 5-HT receptor activation. Alniditan is 10 times more potent than sumatriptan at the h5-HT1B receptor, and twice as potent at the h5-HT1D receptor. 体内研究:In vitro, alniditan exhibits little vasoconstrictive effects on the rat basilar artery, although at a very high concentration 1 mM, alniditan causes intensive constriction, most likely through a mechanism independent from 5-HT receptor activation. Alniditan is 10 times more potent than sumatriptan at the h5-HT1B receptor, and twice as potent at the h5-HT1D receptor.
产品信息订购:
|
相关产品
详细地址
关注
拨打电话
留言咨询