供货周期: | 7天 |
品牌: | 爱必信 |
货号: | abs822424 |
CAS号: | 607736-84-5 |
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抑制剂描述: 产品名称:SUN 1334H 产品别名:见爱必信官网 英文别名:SUN 1334H 靶点:H1 receptor CAS:607736-84-5 纯度: 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder) 描述:SUN 1334H is a potent, orally active, highly selective H1 receptor antagonist, with Ki of 9.7 nM. 溶解性:DMSO* 体外研究: SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum with an IC50 (half the maximal inhibitory concentration) of 0.198 μM. In CHO-K1/hERG cells, SUN-1334H does not modulate hERG K+-currents at concentrations as high as 100 μM. SUN-1334H, cetirizine and hydroxyzine cause comparable inhibition of NLF leukocytes, IL-4 and total protein concentrations. 体内研究:SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum with an IC50 (half the maximal inhibitory concentration) of 0.198 μM. In CHO-K1/hERG cells, SUN-1334H does not modulate hERG K+-currents at concentrations as high as 100 μM. SUN-1334H, cetirizine and hydroxyzine cause comparable inhibition of NLF leukocytes, IL-4 and total protein concentrations.
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