| 供货周期： | 7天 |
| 品牌： | 爱必信 |
| 型号： | >98% |
| 货号： | abs810608 |
| CAS号： | 218156-96-8 |
| 公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!
抑制剂描述： 产品名称：SRPIN 340 产品别名：见爱必信官网 英文别名：SRPIN 340 靶点：SRPK CAS：218156-96-8 纯度：>98% 外观：见爱必信官网 保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months. 描述： SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases.. 溶解性：DMSO 70 mg/mL (200.37 mM) 体外研究： SRPIN340 inhibits SR phosphorylation by SRPK in Flp-In293 cells and promotes degradation of SRp75 in a dose-dependent manner, which subsequently inhibits HIV production. SRPIN340 dose (5 mg/mL) produces no abnormalities in chromosomal structure and chromosome number of CHO cells. SRPIN340 suppresses in a dose-dependent fashion expression of a HCV subgenomic replicon and replication of the HCV-JFH1 clone in vitro. 体内研究：SRPIN340 inhibits CNV formation in a dose-dependent manner in vivo. SRPIN340 significantly decreases the protein levels of VEGF, MCP-1, ICAM-1, and consequently inhibits macrophage infiltration.
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