Galangin|＞98%|abs812954-爱必信(上海)生物科技有限公司

Galangin

参考价：¥446

供货周期：

一周

品牌：

爱必信

规格：

＞98%

货号：

abs812954

CAS号：

548-83-4

产品详情

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抑制剂描述：

产品名称：Galangin

产品别名：见爱必信官网

英文别名：Galangin

靶点：Cytochrome P450;Autophagy

CAS：548-83-4

纯度：＞98%

外观：见爱必信官网

保存方法：Store at -20°C

描述：

Galangin has anti-proliferation effect on HCC cells. Galangin elicits anti-inflammatory effects on LPS-activated macrophages via the inhibition of ERK, NF-κB-p65 and proinflammatory gene expression.

溶解性：DMSO : 27 mg/mL (100 mM)

体外研究：

Galangin inhibits the catabolic breakdown of DMBA, as measured by thin-layer chromatography, in a dose-dependent manner. Galangin also inhibits the formation of DMBA-DNA adducts, and prevents DMBA-induced inhibition of cell growth. Galangin causes a potent, dose-dependent inhibition of CYP1A1 activity, as measured by ethoxyresorufin-O-deethylase activity, in intact cells and in microsomes isolated from DMBA-treated cells. Analysis of the inhibition kinetics by double-reciprocal plot demonstrates that galangin inhibits CYP1A1 activity in a noncompetitive manner. Galangin causes an increase in the level of CYP1A1 mRNA, indicating that it may be an agonist of the aryl hydrocarbon receptor, but it inhibits the induction of CYP1A1 mRNA by DMBA or by 2,3,5,7-tetrachlorodibenzo-p-dioxin (TCDD). Galangin also inhibits the DMBA- or TCDD-induced transcription of a reporter vector containing the CYP1A1 promoter. Galangin treatment inhibits cell proliferation and induced autophagy (130 μM) and apoptosis (370 μM). In particular, galangin treatment in HepG2 cells causes (1) an accumulation of autophagosomes, (2) elevated levels of microtubule-associated protein light chain 3, and (3) an increased percentage of cells with vacuoles. p53 expression is also increased. The galangin-induced autophagy is attenuated by the inhibition of p53 in HepG2 cells, and overexpression of p53 in Hep3B cells restored the galangin-induced higher percentage of cells with vacuoles to normal level.

体内研究：

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs812954	Galangin	5mg	446.00	立即咨询
abs812954	Galangin	10mg	549.00	立即咨询
abs812954	Galangin	25mg	843.00	立即咨询
abs812954	Galangin	50mg	1432.00	立即咨询

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