6-Thioguanine|≥98%|abs814966-爱必信(上海)生物科技有限公司

6-Thioguanine

参考价：¥504

供货周期：

一周

品牌：

爱必信

规格：

≥98%

货号：

abs814966

CAS号：

154-42-7

产品详情

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抑制剂描述：

产品名称：6-Thioguanine

产品别名：见爱必信官网

英文别名：6-Thioguanine

靶点：DNA Methyltransferase

CAS：154-42-7

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20° C

描述：

6-Thioguanine is a chemotherapy drug that demonstrates immunosuppressive, anti-neoplastic, and anti-cancer activities. This chemical is often used to treat leukemia and inflammatory diseases. Chemical produces dose-dependent inhibition of stimulated expression of TRAIL protein.

溶解性：DMSO : 14 mg/mL (83.7 mM)

体外研究：

Thioguanine incorporation alters the DNA cleavage induced by topoisomerase II in the presence and absence of etoposide. 6-Thioguanine alters the structure and lowers the thermal stability of duplex DNA, but duplex DNA can be formed in the presence of 6SG. 6-Thioguanine induced apopotosis is similarly observed in both mismatch repair-proficient and -deficient HCT116 and HeLa cells. Thioguanine integrates into DNA and unlike the canonical DNA bases, it is a strong UVA chromophore with an absorbance maximum at 342 nm. 6-Thioguanine is a photosensitizer and a source of reactive oxygen species. In canine lymphoma cells, Thioguanine significantly decreases DNMT1 protein and global DNA methylation.

体内研究：Thioguanine is as efficient as a PARP inhibitor in selectively killing BRCA2-defective tumors in a xenograft model. 6-Thioguanine efficiently kills such BRCA1-defective PARP inhibitor-resistant tumors. 6-Thioguanine could kill cells and tumors that have gained resistance to PARP inhibitors or cisplatin through genetic reversion of the BRCA2 gene.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs814966	6-Thioguanine	100mg	504.00	立即咨询
abs814966	6-Thioguanine	500mg	1313.00	立即咨询
abs814966	6-Thioguanine	250mg	861.00	立即咨询

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