供货周期: | 7天 |
品牌: | 爱必信 |
型号: | >98% |
货号: | abs817602 |
CAS号: | 1271738-62-5 |
公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!
抑制剂描述: 产品名称:MI-2 (Menin-MLL Inhibitor) 产品别名:见爱必信官网 英文别名:MI-2 (Menin-MLL Inhibitor) 靶点:Histone Methyltransferase CAS:1271738-62-5 纯度:>98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. 溶解性:DMSO : 70 mg/mL (186.4 mM) 体外研究: In HEK293 cells, MI-2 accessed the protein target and effectively inhibits the menin-MLL-AF9 interaction. MI-2 effectively blocks MLL fusion protein-mediated leukemic transformation by downregulating the expression of target genes required for MLL fusion protein oncogenic activity. MI-2 also effectively blocks cell proliferation, and induces cell apoptosis in human MLL leukemia cell lines harboring different MLL translocations. 体内研究:
产品信息订购:
|
详细地址
关注
拨打电话
留言咨询