MSI-1436 lactate||abs820529-爱必信(上海)生物科技有限公司

MSI-1436 lactate

参考价：¥6300

供货周期：

一周

品牌：

爱必信

规格：

货号：

abs820529

CAS号：

1309370-86-2

产品详情

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抑制剂描述：

产品名称：MSI-1436 lactate

产品别名：见爱必信官网

英文别名：MSI-1436 lactate

靶点：Phosphatase

CAS：1309370-86-2

纯度：

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTB1B), with an IC50 of 1 μM, 200-fold preference over TCPTP (IC50 of 224 μM).

溶解性：

体外研究：

In HepG2, MSI-1436 (10 μM, 30 min) alone has no effect on phosphorylation of IRβ, but in conjunction with 100 nM insulin, MSI-1436 increases p-IRβ 18-fold over untreated cells and by approximately threefold over cells treated with insulin alone. MSI-1436's inhibition of TCPTP is approximately two logs less than the effect on PTP1B activity, with a resulting IC50 value of 224 μM. MSI-1436 (Trodusquemine, 10 μM) restores ERK phosphorylation in response to mGluR1/5 agonist DHPG in F11 neuronal cells. MSI-1436 (10 uM) rescues DHPG-induced holding currents and restores DSI in LMO4KO BLA neurons. MSI-1436 (0.1-100 μM) blocks PTP1B activity, has insulin-mimetic effects in cultured neuronal cells.

体内研究：In HepG2, MSI-1436 (10 μM, 30 min) alone has no effect on phosphorylation of IRβ, but in conjunction with 100 nM insulin, MSI-1436 increases p-IRβ 18-fold over untreated cells and by approximately threefold over cells treated with insulin alone. MSI-1436's inhibition of TCPTP is approximately two logs less than the effect on PTP1B activity, with a resulting IC50 value of 224 μM. MSI-1436 (Trodusquemine, 10 μM) restores ERK phosphorylation in response to mGluR1/5 agonist DHPG in F11 neuronal cells. MSI-1436 (10 uM) rescues DHPG-induced holding currents and restores DSI in LMO4KO BLA neurons. MSI-1436 (0.1-100 μM) blocks PTP1B activity, has insulin-mimetic effects in cultured neuronal cells.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs820529	MSI-1436 lactate	1mg	6300.00	立即咨询
abs820529	MSI-1436 lactate	5mg	11970.00	立即咨询

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