Nafamostat mesylate|99%|abs817514-爱必信(上海)生物科技有限公司

Nafamostat mesylate

参考价：¥635

供货周期：

一周

品牌：

爱必信

规格：

99%

货号：

abs817514

CAS号：

82956-11-4

产品详情

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抑制剂描述：

产品名称：Nafamostat mesylate

产品别名：见爱必信官网

英文别名：Nafamostat mesylate

靶点：Ser/Thr Protease

CAS：82956-11-4

纯度：99%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Nafamostat mesilate is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis.

溶解性：DMSO : 54 mg/mL (100 mM)
water : 54 mg/mL (100 mM)l

体外研究：

Nafamostat mesilate significantly inhibits the release of platelet beta-thromboglobulin (beta TG) at 60 and 120 min. Nafamostat mesilate (NM) prevents any significant release of neutrophil elastase; at 120 min, plasma elastase-alpha 1-antitrypsin complex is 0.16 mg/mL in the NM group and 1.24 mg/mL in the control group. Nafamostat mesilate completely inhibits formation of complexes of C1 inhibitor with kallikrein and FXIIa. Nafamostat mesilate inhibits several proteases which may be importantly involved in the pathophysiology of disseminated intravascular coagulation (DIC).Nafamostat mesilate inhibits extrinsic pathway activity (TF-F.VIIa mediated-F.Xa generation) in a concentration dependent manner with IC50 of 0.1 μM. Nafamostat mesilate produces concentration-dependent inhibition of the initial-phase transient component of biphasic ASIC3 currents with an IC50 value of approximately 2.5 mM.

体内研究：Nafamostat mesilate (10 mg/kg) inhibits scratching induced by tryptase but not by histamine and serotonin. Nafamostat mesilate (1-10 mg/kg) produces the dose-dependent inhibition of scratching induced by intradermal compound 48/80 (10 mg/site). Nafamostat mesilate (10 mg/kg) suppresses tryptase activity in the mouse skin. Nafamostat mesilate inhibits gemcitabine-induced NF-kappaB activation, enhances apoptosis by gemcitabine and suppresses pancreatic tumor growth. Nafamostat mesilate combined with Gemcitabine improves the body weight loss of mice induced by Gemicitabine.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs817514	Nafamostat mesylate	10mg	635.00	立即咨询
abs817514	Nafamostat mesylate	25mg	1062.00	立即咨询
abs817514	Nafamostat mesylate	50mg	1833.00	立即咨询
abs817514	Nafamostat mesylate	100mg	2684.00	立即咨询

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