BI605906|>98%|abs811360-爱必信(上海)生物科技有限公司

BI605906

参考价：¥5198

供货周期：

一周

品牌：

爱必信

规格：

>98%

货号：

abs811360

CAS号：

960293-88-3

产品详情

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

抑制剂描述：

产品名称：BI605906

产品别名：见爱必信官网

英文别名：BI605906

靶点：IKK

CAS：960293-88-3

纯度：>98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

BI605906 is a novel inhibitors of the IKK beta.

溶解性：DMSO: ≥ 29 mg/mL

体外研究：

BI605906 is an inhibitor of IKKβ with improved selectivity. BI605906 inhibits IKKβ in vitro with an IC50 value of 380 nM when assayed at 0.1 mM ATP. The only other protein kinase that is inhibited of over 100 tested, which include IKKα, IKKε and TBK1, is the insulin-like growth factor 1 (IGF1) receptor (IC50=7.6 μM). BI605906 partially inhibits the IL-1-stimulated activation of IKKε/TBK1. In primary mouse hepatocytes, Metformin treatment for 3 hours suppresses TNFα-induced degradation of the NF-κB negative regulator IκB, while modulating AMPK and MTOR signaling in a dose-dependent manner. The magnitude of the effect on IκB is comparable with BI605906. Unlike Metformin, BI605906 (10 μM ) does not suppress signaling downstream of mTOR nor does it activate AMPK. TNF-α-dependent expression of CINC-1/CXCL1, CXCL2, IL-1β, and IL-6 is strongly inhibited by both Metformin and BI605906 (10 μM).

体内研究：

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs811360	BI605906	10mg	5198.00	立即咨询
abs811360	BI605906	5mg	2888.00	立即咨询

产品更多信息请进入爱必信网站咨询