总的来说,就萃出的化合物种类而言,所有方法大体相当。但是,经过确定,如果时间和资源成为重要的因素,则超临界流体萃取法相对于其他萃取方法具有诸多优势。MV-10 ASFE系统由软件控制,可进行自动化的方法开发。可使用的共溶剂达4种之多,在方法中可设定各种比例和萃取时间。在方法开发中,索氏萃取和微波萃取需要手动更换每一操作步骤的溶剂进行质量设计研究时,相当费时。 结论
与索氏萃取法相比,超临界流体萃取法可减少80%至97%的溶剂消耗量,同时可减少75%的萃取时间。通过软件控制的超临界萃取法使自动化方法开发能够确定最佳的萃取溶剂的比例和溶剂的选择。此外,与微波萃取法相比,超临界流体萃取法提供了样品预浓缩操作的灵活性。 参考文献
1. Containers Closure Systems for Packaging Human Drugs and Biologics; Guidance for Industry; U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) and Center for Biologics Evaluation and Research (CBER); Rockville, MD. 1999 May.
2. Norwood DL, Fenge Q. Strategies for the analysis of pharmaceutical excipients and their trace level impurities. Am Pharm Rev. 2004;7(5): 92,94,96-99.
3. Ariasa M, Penichet I, Ysambertt F, Bauza R, Zougaghc M, Ríos Á. Fast supercritical fluid extraction of low- and high-density polyethylene additives: Comparison with conventional reflux and automatic Soxhlet extraction. J Supercritical Fluids. 2009; 50: 22-28.
4. Cabovska B, Jones MD, Aubin A. Application of UPC2 in extractables analysis. Waters Application Note 720004490en. 2012 November. 下载完整清晰应用纪要 请点击:http://www.waters.com/waters/library.htm?lid=134715590&cid=511436
总的来说,就萃出的化合物种类而言,所有方法大体相当。但是,经过确定,如果时间和资源成为重要的因素,则超临界流体萃取法相对于其他萃取方法具有诸多优势。MV-10 ASFE系统由软件控制,可进行自动化的方法开发。可使用的共溶剂达4种之多,在方法中可设定各种比例和萃取时间。在方法开发中,索氏萃取和微波萃取需要手动更换每一操作步骤的溶剂进行质量设计研究时,相当费时。 结论
与索氏萃取法相比,超临界流体萃取法可减少80%至97%的溶剂消耗量,同时可减少75%的萃取时间。通过软件控制的超临界萃取法使自动化方法开发能够确定最佳的萃取溶剂的比例和溶剂的选择。此外,与微波萃取法相比,超临界流体萃取法提供了样品预浓缩操作的灵活性。 参考文献
1. Containers Closure Systems for Packaging Human Drugs and Biologics; Guidance for Industry; U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) and Center for Biologics Evaluation and Research (CBER); Rockville, MD. 1999 May.
2. Norwood DL, Fenge Q. Strategies for the analysis of pharmaceutical excipients and their trace level impurities. Am Pharm Rev. 2004;7(5): 92,94,96-99.
3. Ariasa M, Penichet I, Ysambertt F, Bauza R, Zougaghc M, Ríos Á. Fast supercritical fluid extraction of low- and high-density polyethylene additives: Comparison with conventional reflux and automatic Soxhlet extraction. J Supercritical Fluids. 2009; 50: 22-28.
4. Cabovska B, Jones MD, Aubin A. Application of UPC2 in extractables analysis. Waters Application Note 720004490en. 2012 November. 下载完整清晰应用纪要 请点击:http://www.waters.com/waters/library.htm?lid=134715590&cid=511436