英文名称  Anti-GDF8 

中文名称  生长分化因子8/肌肉抑制素抗体 

别    名  MSTN; growth differntiation factor 8; GDF 8; Growth differentiation factor 8; Growth/Differentiation Factor 8; myostatin. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg     

生长分化因子8/肌肉抑制素抗体抗体来源  Goat  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow

产品类型  一抗    

研究领域  免疫学 生长因子和激素 细胞分化  

蛋白分子量  predicted molecular weight: 12/43kDa 

性    状  Lyophilized or Liquid 

免 疫 原  Recombinant fusion protein, His tagged 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

生长分化因子8/肌肉抑制素抗体产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Myostatin (GDF8)is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma. Myostatin is a member of the transforming growth factor beta superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass. Studies have shown that myostatin could play an important role in cardiac development and physiology.

Subunit : Homodimer; disulfide-linked.

Subcellular Location : Secreted.

Tissue Specificity : Predominantly expressed in muscle. At hatching, expression is strongest in the skin epithelium, and is also found in the retina and brain. From day 28, expressed in skeletal muscle. In the adult, highest expression is seen in the gastrointestinal tract, brain, muscle, heart and testis. Also expressed in the adult pharynx, kidney, spleen, liver, gill, eyes, skin, swim bladder and ovary.

生长分化因子8/肌肉抑制素抗体Similarity : Belongs to the TGF-beta family.

GDF-8又称MSTN,是转化生长因子超家族，也是近年来发现的一类重要的肌细胞生长调控因子，它通过抑制MyoD家族成员转录活性负向控制肌细胞的生长发育，它的表达量与肌肉重量的变化呈负相关。