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抑制剂描述： 产品名称：SU-9516 产品别名：见爱必信官网 英文别名：SU-9516 靶点：CDK CAS：666837-93-0 纯度：98% 外观：见爱必信官网 保存方法：Store at -20° C 描述： SU-9516 is a 3-substituted indolinone compound displaying anti-proliferative and proapoptotic properties in tumor cells. SU-9516 displays activity as a selectively potent ATP-competitive inhibitor of CDKs. It also shows no significant effect (IC50 >10 μM) on the activities of PKC, p38, PDGFRβ, or EGFR. SU-9516 has an Inhibitory effect on proliferation of growth-factor stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F. SU-9516 is an inhibitor of Cdc2, Cdk2 and Cdk4. 溶解性：Soluble in DMSO (10 mg/ml), and ethanol (20 mM). Insoluble in water. 体外研究： 体内研究：
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