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抑制剂描述： 产品名称：JI051 产品别名：见爱必信官网 英文别名：JI051 靶点：Notch CAS：2234281-75-3 纯度： 外观：见爱必信官网 保存方法：store at -20℃ for one year（Powder） 描述：JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene HesAnti-cancer activity. 溶解性： 体外研究： JI051 causes G2/M cell-cycle arrest.JI051 (0.1-10 μM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM.Cell Proliferation AssayCell Line:HEK293 cellsConcentration:0.1-10 μMIncubation Time:24 hoursResult:Dose-dependently inhibits the proliferation of HEK293 cells at low concentrations. 体内研究：JI051 causes G2/M cell-cycle arrest.JI051 (0.1-10 μM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM.Cell Proliferation AssayCell Line:HEK293 cellsConcentration:0.1-10 μMIncubation Time:24 hoursResult:Dose-dependently inhibits the proliferation of HEK293 cells at low concentrations.
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