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抑制剂描述： 产品名称：Quinidine sulfate dihydrate 产品别名：见爱必信官网 英文别名：Quinidine sulfate dihydrate 靶点：Sodium Channel CAS：6591-63-5 纯度：98% 外观：见爱必信官网 保存方法：Store at -20° C 描述： Quinidine sulfate dihydrate is a diastereomer of quinine and a Na+ channel blocker. Also a class I antiarrhythmic drug. 溶解性： 体外研究： Quinidine selectively reduces the proliferation of merlin-deficient HMM cell lines by causing a G0/G1 arrest, whereas the proliferation rates of merlinexpressing HMM cell lines remain unchanged. In addtion to its function as a channel blocker, quinidine is an inhibitor of a specific isoform of the cytochrome P450 family (CYP2D6), which is involved in the detoxification and metabolism of multiple commonly prescribed drugs as well as numerous endogenous substrates. 体内研究：Quinidine is a potent and selective inhibitor of P450db and that quinidine can inhibit the in vivo metabolism of debrisoquine in humans. Quinidine is an inhibitor of amphetamine metabolism in vivo.
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