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抑制剂描述: 产品名称:Quinidine sulfate dihydrate 产品别名:见爱必信官网 英文别名:Quinidine sulfate dihydrate 靶点:Sodium Channel CAS:6591-63-5 纯度:98% 外观:见爱必信官网 保存方法:Store at -20° C 描述: Quinidine sulfate dihydrate is a diastereomer of quinine and a Na+ channel blocker. Also a class I antiarrhythmic drug. 溶解性: 体外研究: Quinidine selectively reduces the proliferation of merlin-deficient HMM cell lines by causing a G0/G1 arrest, whereas the proliferation rates of merlinexpressing HMM cell lines remain unchanged. In addtion to its function as a channel blocker, quinidine is an inhibitor of a specific isoform of the cytochrome P450 family (CYP2D6), which is involved in the detoxification and metabolism of multiple commonly prescribed drugs as well as numerous endogenous substrates. 体内研究:Quinidine is a potent and selective inhibitor of P450db and that quinidine can inhibit the in vivo metabolism of debrisoquine in humans. Quinidine is an inhibitor of amphetamine metabolism in vivo.
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