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抑制剂描述：

产品名称：Cuspin-1

产品别名：见爱必信官网

英文别名：Cuspin-1

靶点：Others

CAS：337932-29-3

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20℃

描述：

The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA). Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 μM. Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation.

溶解性：DMSO ：16mg/ml

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体内研究：

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