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抑制剂描述：

产品名称：MI-2 (Menin-MLL Inhibitor)

产品别名：见爱必信官网

英文别名：MI-2 (Menin-MLL Inhibitor)

靶点：Histone Methyltransferase

CAS：1271738-62-5

纯度：＞98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.

溶解性：DMSO : 70 mg/mL (186.4 mM)
Ethanol : 70 mg/mL (186.4 mM)

体外研究：

In HEK293 cells, MI-2 accessed the protein target and effectively inhibits the menin-MLL-AF9 interaction. MI-2 effectively blocks MLL fusion protein-mediated leukemic transformation by downregulating the expression of target genes required for MLL fusion protein oncogenic activity. MI-2 also effectively blocks cell proliferation, and induces cell apoptosis in human MLL leukemia cell lines harboring different MLL translocations.

体内研究：

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