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试剂描述: 产品名称:PMA 产品别名:佛波醇12-十四酸酯13-乙酸酯(佛波酯);12-十四酸酯13-乙酸佛波醇酯;Phorbol-12-Myristate-13-Acetate CAS号:16561-29-8 英文别名:PMA 分子量:616.83 分子式:C36H56O8 纯度:≥98% 外观:见爱必信官网 保存方法:Store at -20° C,3 years. 描述: PMA (Phorbol-12-Myristate-13-Acetate) is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. PMA’s effects on PKC are attributed to its similarity to diacylgylerol, a natural activator of PKC. PMA activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells. 应用:A reversible and highly potent protein kinase C (PKC) activator
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