方案摘要
方案下载| 应用领域 | 医疗/卫生 |
| 检测样本 | 全血/血清/血浆 |
| 检测项目 | |
| 参考标准 | Schwope, D. M.; Scheidweiler, K. B.; Huestis, M. Anal Bioanal Chem 2011 Sep, 401(4), 1273-1283. |
We demonstrated a simple and economical quantitative method for analysis of THC and metabolites in blood for forensics. Method performance meets forensic lab requirements. Analysis of glucuronides allows for better data interpretation to determine recent cannabis intake. To improve laboratory throughput by 30%, this method can be implemented on a 2-channel Thermo Scientific™ Transcend™ II LC system to provide data for 17 samples per hour.
To demonstrate a simple and economical quantitative method for the
analysis of THC and THC metabolites in blood to address key forensic
laboratory requirements.
Cannabis is the most frequently abused drug. THC
(tetrahydrocannabinol) is the major psychoactive
constituent of cannabis. THC is primarily metabolized
to 11-hydroxy-THC (THC-OH), which has equipotent
psychoactivity and is further metabolized to non-
psychoactive 11-nor-9-carboxy-THC (THC-COOH).
Second-phase metabolites, THC-glucuronide and
THC-COOH-glucuronide, are also present in blood
and can be used as markers to determine recency of
cannabis intake and to improve interpretation of analytical
results.1 LC-MS analytical methods are widely used for
analysis of THC and its metabolites in blood samples.
LC-MS methods do not require sample derivatization,
thus yielding savings over typical GC-MS procedures.
We demonstrated a simple and economical quantitative
method for analysis of THC and metabolites in blood for
forensics. Method performance meets forensic lab
requirements. Analysis of glucuronides allows for better
data interpretation to determine recent cannabis intake.
To improve laboratory throughput by 30%, this method
can be implemented on a 2-channel Thermo Scientific™
Transcend™ II LC system to provide data for 17 samples
per hour.
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