使用SOLAμ板样品制备和TSQ Endura三重四极杆质谱仪联用进行临床研究中血浆甲基丙二酸的定量检测

2018/03/13   下载量： 6 次

方案摘要

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应用领域 医疗/卫生
检测样本 全血/血清/血浆
检测项目
参考标准 TSQ

We demonstrated a sensitive and robust method for quantifying MMA in plasma that provides a wide dynamic range, while employing simple and economical sample preparation. With the short run time and data acquisition window, this analytical method can be put into use on a 4-channel Thermo Scientific™ Transcend™ II LC system to address high-throughput analysis (50 samples/hour) requirement in clinical research.

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To demonstrate a sensitive, robust, reliable quantitative analysis of
methylmalonic acid in plasma for clinical research.

Liquid chromatography-mass spectrometry (LC-MS)
analytical methods are widely used for quantitation of
methylmalonic acid (MMA) in clinical research
laboratories. The quantitation of MMA poses several
challenges, including (i) the need for a simple sample
preparation method; (ii) achievement of low limits of
quantitation; and (iii) separation from the naturally
occurring structural isomer succinic acid. Here we present
an analytical method that successfully addresses all of
these requirements.

We demonstrated a sensitive and robust method for
quantifying MMA in plasma that provides a wide dynamic
range, while employing simple and economical sample
preparation. With the short run time and data acquisition
window, this analytical method can be put into use on a
4-channel Thermo Scientific™ Transcend™ II LC system to
address high-throughput analysis (50 samples/hour)
requirement in clinical research.

上一篇 高压离子色谱Inuvion快速测定自来水中的常见阴离子
下一篇 使用TSQ Altis三重四极杆质谱仪对血浆中候选药物混合物进行灵敏、稳健的定量分析

文献贡献者

赛默飞色谱与质谱
钻石会员 丨 第23年
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