耳蜗内的近红外模拟：原位声光模拟的可行性研究

2019/01/23   下载量： 2 次

方案摘要

方案下载
应用领域 医疗/卫生
检测样本 其他
检测项目
参考标准 暂无

立陶宛Ekspla公司生产的光学参量振荡器，型号NT342A，重复频率10赫兹。脉冲宽度5纳秒。输出波长420-2300纳米。实验中采用的近红外激光峰值功率2千瓦，单脉冲能量1-15微焦。以此为光源，对人内耳蜗的原位声光模拟进行了研究分析。

方案下载
配置单
方案详情

Intracochlear optical stimulation has been suggested as an alternative approach to hearing prosthetics in recent years. This study investigated the properties of a near infrared laser (NIR) induced optoacoustic effect. Pressure recordings were performed at the external meatus of anaesthetized guinea pigs during intracochlear NIR stimulation. The sound pressure and power spectra were determined. The results were compared to multi unit responses in the inferior colliculus (IC). Additionally, the responses to NIR stimulation were compared to IC responses induced by intracochlear electric stimulation at the same
cochlear position to investigate a potentially confounding contribution of direct neural NIR stimulation.The power spectra of the sound recorded at the external meatus (n ¼ 7) had most power at frequencies below 10 kHz and showed little variation for different stimulation sites. The mean spike rates of IC units responding to intracochlear NIR stimulation (n ¼ 222) of 17 animals were significantly correlated with the power of the externally recorded signal at frequencies corresponding to the best frequencies of the IC units. The response strength as well as the sound pressure at the external meatus depended on the pulse peak power of the optical stimulus. The sound pressure recorded at the external meatus reached levels
above 70 dB SPL peak equivalent. In hearing animals a cochlear activation apical to the location of the fiber was found. The absence of any NIR responses after pharmacologically deafening and the comparison to electric stimulation at the NIR stimulation site revealed no indication of a confounding direct neural NIR stimulation. Intracochlear optoacoustic stimulation might become useful in combined electro-acoustic stimulation devices in the future.

上一篇 在一个双稳湍流涡旋火焰中，对间歇性动态的时间-频率定位
下一篇 商用铁电存储器（FRAM）单粒子事件效应及应用中子诱导位移破坏的缓解技术

文献贡献者

北京欧兰科技发展有限公司
金牌会员 丨 第17年
查看全部资料
推荐方案
更多

相关产品

当前位置： 仪器信息网 欧兰科技 方案 耳蜗内的近红外模拟：原位声光模拟的可行性研究

关注

拨打电话

留言咨询