供货周期: | 现货 |
品牌: | 康朗生物 |
规格: | 0.1ml/0.2ml |
货号: | KL12970R |
CAS号: |
Quantity size:
0.1ml
Concentration:
1mg/ml 磷酸化α晶状体球蛋白B/αB-crystallin抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, 磷酸化α晶状体球蛋白B/αB-crystallin抗体making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although 磷酸化α晶状体球蛋白B/αB-crystallin抗体they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008].
磷酸化α晶状体球蛋白B/αB-crystallin抗体Also known as:
alpha B Crystallin (phospho S45); alpha B Crystallin (phospho Ser45); p-alpha B Crystallin (S45); p-alpha B Crystallin (Ser45); AACRYA; Alpha B crystallin; Alpha crystallin B chain; Alpha crystallin B chain; Alpha(B) crystallin; Alpha(B)-crystallin; Alpha-crystallin B chain; CRYA2; CRYAB; CRYAB_HUMAN; Crystallin alpha B; Crystallin alpha polypeptide 2; CTPP 2; CTPP2; Heat shock 20 kD like protein; Heat shock protein beta 5; Heat shock protein beta-5; HSPB5; NY REN 27 antigen; Renal carcinoma antigen NY REN 27; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, .
●
Immunogen: KLH conjugated synthesised phosphopeptide derived from human alpha B Crystallin around the phosphorylation site of Ser45.
●
磷酸化α晶状体球蛋白B/αB-crystallin抗体Predicted Molecular Weight: 20kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
kl902Hu01心肌钙黏蛋白(CDHH)多克隆抗体Polyclonal Antibody to Cadherin, Heart (CDHH)
kl903Hu01纤维胶凝蛋白3(FCN3)多克隆抗体Polyclonal Antibody to Ficolin 3 (FCN3)
kl904Hu01血小板膜糖蛋白Ⅵ(GP6)多克隆抗体Polyclonal Antibody to Glycoprotein VI, Platelet (GP6)
kl905Hu01白介素7受体(IL7R)多克隆抗体Polyclonal Antibody to Interleukin 7 Receptor (IL7R)
kl905Ra01白介素7受体(IL7R)多克隆抗体Polyclonal Antibody to Interleukin 7 Receptor (IL7R)
kl907Hu01纤维胶凝蛋白2(FCN2)多克隆抗体Polyclonal Antibody to Ficolin 2 (FCN2)
kl908Hu01聚集蛋白聚糖(AGC)多克隆抗体Polyclonal Antibody to Aggrecan (AGC)
kl908Mu01聚集蛋白聚糖(AGC)多克隆抗体Polyclonal Antibody to Aggrecan (AGC)
kl908Ra01聚集蛋白聚糖(AGC)多克隆抗体Polyclonal Antibody to Aggrecan (AGC)
kl909Hu01p53上调凋亡调节因子(PUMA)多克隆抗体Polyclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA)
kl909Ra01p53上调凋亡调节因子(PUMA)多克隆抗体Polyclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA)
kl910Hu01激肽释放酶7(KLK7)多克隆抗体Polyclonal Antibody to Kallikrein 7 (KLK7)
kl910Mu01激肽释放酶7(KLK7)多克隆抗体Polyclonal Antibody to Kallikrein 7 (KLK7)
kl912Hu01防御素α5(DEFα5)多克隆抗体Polyclonal Antibody to Defensin Alpha 5, kleth Cell Specific (DEFa5)
kl914Hu01甲酰肽受体2(FPR2)多克隆抗体Polyclonal Antibody to Formyl Peptide Receptor 2 (FPR2)
kl915Hu01布鲁东氏酪氨酸激酶(Btk)多克隆抗体Polyclonal Antibody to Bruton'S Tyrosine Kinase (Btk)
kl918Mu01蛋白激酶Cα(PKCα)多克隆抗体Polyclonal Antibody to Protein Kinase C Alpha (PKCa)
kl918Ra01蛋白激酶Cα(PKCα)多克隆抗体Polyclonal Antibody to Protein Kinase C Alpha (PKCa)
kl919Hu01血管生成素样蛋白2(ANGPTL2)多克隆抗体Polyclonal Antibody to Angiopoietin Like Protein 2 (ANGPTL2)
相关产品
关注
拨打电话
留言咨询