肽基脯氨酰顺反异构酶FKBP10抗体

参考价:面议
供货周期: 现货
品牌: 康朗生物
规格: 0.1ml/0.2ml
货号: KL13175R
CAS号:
上海康朗生物科技有限公司
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产品详情

Quantity size:

0.2ml

Concentration:

1mg/ml 肽基脯氨酰顺反异构酶FKBP10抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin. Immunophilins have also been implicated in protein folding and trafficking within the肽基脯氨酰顺反异构酶FKBP10抗体  endoplasmic reticulum (ER). FKBP10 (FK506-binding protein 10), also known as peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase, 65kDa FK506-binding protein or FKBP65, is a 582 amino acid immunophilin localized to the ER lumen and found in many tissues including heart, spleen, brain, testis and lung. FKBP10 contains two EF-hand calcium-binding domains and four PPIase FKBP-type domains, suggesting an enzymatic role in protein folding by catalyzing the肽基脯氨酰顺反异构酶FKBP10抗体  cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FKBP10 also acts as a receptor for the immunosuppressants FK506 and rapamycin, which inhibit FKBP10 activity. FKBP10 is thought to interact with the Raf-1/HSP 90 heterocomplex during signal transduction processes, and may associate with elastin during elastin protein folding and transport. With a valine-24 addition to human FKBP10, human and mouse FKBP10 are almost identical.

肽基脯氨酰顺反异构酶FKBP10抗体 Also known as:

65 kDa FK506 binding protein; FK506 binding protein 10 65 kDa; FK506 binding protein 10; FKBP 10; FKBP 65; hFKBP 65; Immunophilin FKBP65; Peptidyl prolyl cis trans isomerase. PPIase; Rotamase; FKB10_HUMAN.

Specificity:

Rabbit Polyclonal IgG, affinity purified by Protein A.

Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, .

Immunogen: KLH conjugated synthetic peptide derived from human FKBP10.

肽基脯氨酰顺反异构酶FKBP10抗体 Predicted Molecular Weight: 61kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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