间隙连结蛋白50/白内障相关蛋白抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 间隙连结蛋白50/白内障相关蛋白抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The connexin family of proteins form hexameric complexes called “connexons” that facilitate movement of low molecular weight proteins between cells via gap junctions (1). Connexin proteins share a common topology of 4 transmembrane alpha-helical domains, two extracellular loops, a cytoplasmic loop, and cytoplasmic N- and C-termini (2). Many of间隙连结蛋白50/白内障相关蛋白抗体 the key functional differences arise from specific amino-acid substitutions in the most highly conserved domains, the transmembrane and extracellular regions (2). Each of the approximately 20 connexin isoforms produces channels with distinct permeabilities and electrical and chemical sensitivities; therefore, one connexin usually cannot fully substitute for 间隙连结蛋白50/白内障相关蛋白抗体another (2). Consequently, a wide variety of malignant phenotypes associate with decreased connexin expression and gap junction communication, dependent on the particular connexin that is effected (3, 2). For instance, deletion of the gene encoding connexin 50, normally expressed in the lens, produces cataracts, though not as severe as with deletion of connexin 46 (4).

Also known as:

CAE; CAE1; cataract, zonular pulverulent 1 (FY-linked); Connexin 50; Connexin50; Connexin-50; Cx50; CXA8_HUMAN; 间隙连结蛋白50/白内障相关蛋白抗体Gap junction alpha 8 protein; Gap junction alpha-8 protein; Gap junction membrane channel protein alpha 8 (connexin 50); gap junction protein, alpha 8, 50kD; Gja8; Lens fiber protein MP70.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep, .

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Immunogen: KLH conjugated synthetic peptide derived from human GJA8/Con.

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间隙连结蛋白50/白内障相关蛋白抗体Predicted Molecular Weight: 48kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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