鸟苷酸环化酶/GCS-β-2/GCS-β2抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 鸟苷酸环化酶/GCS-β-2/GCS-β2抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility,  鸟苷酸环化酶/GCS-β-2/GCS-β2抗体platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one ?subunit and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both  鸟苷酸环化酶/GCS-β-2/GCS-β2抗体alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver

Also known as:

GC SB2; GCS BETA 2; GTP pyrophosphate lyase; Guanylate cyclase 1 soluble beta 2; GCYA2_HUMAN; Guanylate cyclase  鸟苷酸环化酶/GCS-β-2/GCS-β2抗体soluble beta 2; Guanylate cyclase soluble beta 2 chain; Guanylate cyclase soluble subunit beta 2; Gucy1b2; Gucy1b2a; Gucy1b2b; SGC; Soluble guanylate cyclase beta 2.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Pig, Horse, .

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Immunogen: KLH conjugated synthetic peptide derived from human Guanylat.

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 鸟苷酸环化酶/GCS-β-2/GCS-β2抗体Predicted Molecular Weight: 82kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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