供货周期: | 现货 |
品牌: | 康朗生物 |
规格: | 0.1ml/0.2ml |
货号: | KL0047R |
CAS号: |
Quantity size:
0.2ml
Concentration:
1mg/ml 胰岛素受体α抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity.胰岛素受体α抗体 RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.
Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates胰岛素受体α抗体 receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.
胰岛素受体α抗体Also known as:
CD 220; CD220; CD220 antigen; HHF 5; HHF5; INSR; IR; 4932439J01Rik; ALPHA SUBUNIT INSULIN RECEPTOR; D630014A15Rik; INSULIN RECEPTOR; INSULIN RECEPTOR KINASE; INSULIN RPTK; IR ALPHA; IRK; INSR_HUMAN.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, .
●
Immunogen: KLH conjugated synthetic peptide derived from human Insulin .
●
胰岛素受体α抗体Predicted Molecular Weight: 80kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
l277Ga01间隙连接蛋白43(CX43)多克隆抗体Polyclonal Antibody to Connexin 43 (CX43)
kl277Hu01间隙连接蛋白43(CX43)多克隆抗体Polyclonal Antibody to Connexin 43 (CX43)
kl277Mu01间隙连接蛋白43(CX43)多克隆抗体Polyclonal Antibody to Connexin 43 (CX43)
kl277Po01间隙连接蛋白43(CX43)多克隆抗体Polyclonal Antibody to Connexin 43 (CX43)
kl277Ra01间隙连接蛋白43(CX43)多克隆抗体Polyclonal Antibody to Connexin 43 (CX43)
kl277Rb51间隙连接蛋白43(CX43)多克隆抗体Polyclonal Antibody to Connexin 43 (CX43)
kl277Si01间隙连接蛋白43(CX43)多克隆抗体Polyclonal Antibody to Connexin 43 (CX43)
kl278Fi01踝蛋白(TLN)多克隆抗体Polyclonal Antibody to Talin (TLN)
kl278Ga01踝蛋白(TLN)多克隆抗体Polyclonal Antibody to Talin (TLN)
kl278Hu01踝蛋白(TLN)多克隆抗体Polyclonal Antibody to Talin (TLN)
kl278Mu01踝蛋白(TLN)多克隆抗体Polyclonal Antibody to Talin (TLN)
kl280Hu01钙联蛋白(CNX)多克隆抗体Polyclonal Antibody to Calnexin (CNX)
kl281Ga01B-细胞激活因子受体(BAFFR)多克隆抗体Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR)
kl281Hu01B-细胞激活因子受体(BAFFR)多克隆抗体Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR)
kl281Mu01B-细胞激活因子受体(BAFFR)多克隆抗体Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR)
kl284Ga01肝素辅因子Ⅱ(HCⅡ)多克隆抗体Polyclonal Antibody to Heklin Cofactor II (HCII)
kl284Hu01肝素辅因子Ⅱ(HCⅡ)多克隆抗体Polyclonal Antibody to Heklin Cofactor II (HCII)
kl284Mu01肝素辅因子Ⅱ(HCⅡ)多克隆抗体Polyclonal Antibody to Heklin Cofactor II (HCII)
kl284Ra01肝素辅因子Ⅱ(HCⅡ)多克隆抗体Polyclonal Antibody to Heklin Cofactor II (HCII)
kl284Rb51肝素辅因子Ⅱ(HCⅡ)多克隆抗体Polyclonal Antibody to Heklin Cofactor II (HCII)
kl292Ga01α-胞衬蛋白(SPTAN1)多克隆抗体Polyclonal Antibody to Alpha-Fodrin (SPTAN1)
kl292Hu01α-胞衬蛋白(SPTAN1)多克隆抗体Polyclonal Antibody to Alpha-Fodrin (SPTAN1)
kl292Mu01α-胞衬蛋白(SPTAN1)多克隆抗体Polyclonal Antibody to Alpha-Fodrin (SPTAN1)
kl292Ra01α-胞衬蛋白(SPTAN1)多克隆抗体Polyclonal Antibody to Alpha-Fodrin (SPTAN1)
相关产品
关注
拨打电话
留言咨询