磷酸化胰岛素样生长因子1受体抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化胰岛素样生长因子1受体抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R  磷酸化胰岛素样生长因子1受体抗体and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

 磷酸化胰岛素样生长因子1受体抗体Also known as:

IGF1 Receptor (phospho Y1161); p-IGF1 Receptor (phospho Y1161); IGF1R (phospho-Tyr1161); IGF1R (phospho-Y1161); p-IGF1R (Tyr1161); p-IGF1R (Y1161); IGF1R (phospho Tyr1161); CD221; CD221; CD221 antigen; IGF 1 receptor; IGF 1R; IGF 1R; IGF I receptor; IGF-I receptor; IGF1R; IGF1R; IGF1R_HUMAN; IGFIR; IGFIRC; IGFIRC; IGFR; Insulin like growth factor 1 receptor; 磷酸化胰岛素样生长因子1受体抗体 Insulin like growth factor 1 receptor; Insulin like growth factor 1 receptor precursor; Insulin like growth factor 1 receptor precursor; Insulin-like growth factor 1 receptor beta chain; Insulin-like growth factor I receptor; JTK13; JTK13;

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human.

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 磷酸化胰岛素样生长因子1受体抗体Predicted Molecular Weight: 71/80kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:50-300  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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