磷酸化组蛋白去甲基化酶JMJD2B抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化组蛋白去甲基化酶JMJD2B抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

JMJD2B is a 1,064 amino acid protein encoded by the human gene JMJD2B. JMJD2B belongs to the JMJD2B histone demethylase family and contains one JmjC domain, one JmjN domain, two PHD-type zinc fingers and two Tudor domains. The two Tudor domains recognize and bind methylated histones and have an interdigitated structure; the unusual fold is required for its 磷酸化组蛋白去甲基化酶JMJD2B抗体ability to bind methylated histone tails. JMJD2B is a histone demethylase that specifically demethylates Lys 9 residues of Histone H3, thereby playing a role in histone code. It does not demethylate Histone H3 Lys 4, H3 Lys 27, H3 Lys 36 or H4 Lys 20, however, and is only able to demethylate trimethylated H3 Lys-9 and has weaker activity than JMJD2A, JMJD2C and JMJD2D. JMJD2B demethyl-ation of Lysine residues will generate formaldehyde and succinate. JMJD2B is a ubiquitously expressed nuclear protein.

磷酸化组蛋白去甲基化酶JMJD2B抗体Also known as:

KDM4B / JMJD2B (phospho T305); KDM4B/JMJD2B (phospho T305); KDM4B/JMJD2B (phospho Thr305); p-KDM4B(T305); p-KDM4B(Thr305); JHDM3B; JmjC domain-containing histone demethylation protein 3B; JMJD2B; JmjC domain-containing histone demethylation protein 3A; Jumonji domain containing protein 2B; KIAA0876; Lysine-specific demethylase 4B; KDM4B_HUMAN.

Specificity:

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Rabbit Polyclonal IgG,磷酸化组蛋白去甲基化酶JMJD2B抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Cow, Sheep, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human.

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Predicted Molecular Weight: 122kDa.

磷酸化组蛋白去甲基化酶JMJD2B抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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