磷脂酸磷酸酯酶LPIN1抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 磷脂酸磷酸酯酶LPIN1抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1)磷脂酸磷酸酯酶LPIN1抗体 is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 磷脂酸磷酸酯酶LPIN1抗体may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.

磷脂酸磷酸酯酶LPIN1抗体Also known as:

KIAA0188; LPIN1; PAP1; Phosphatidate phosphatase LPIN1; LPIN1_HUMAN.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Mouse, Rat, Dog, Pig, Cow, Rabbit, Goose, Sheep, Chimpanzee, .

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Immunogen: KLH conjugated synthetic peptide derived from human Lipin 1.

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Predicted Molecular Weight: 99 kDa.

磷脂酸磷酸酯酶LPIN1抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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