磷酸化单丝氨酸蛋白激酶1抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化单丝氨酸蛋白激酶1抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that磷酸化单丝氨酸蛋白激酶1抗体 regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]

磷酸化单丝氨酸蛋白激酶1抗体Also known as:

LIM Kinase 1 (phospho T508); p-LIM Kinase 1 (phospho T508); LIMK1 (phospho T508);p-LIMK1 (phospho T508); EC 2.7.1.37; LIM domain containing protein kinase; LIM domain kinase 1; LIM motif containing protein kinase; LIMK 1; LIMK; LIMK-1; limk1; LIMK1_HUMAN.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, 磷酸化单丝氨酸蛋白激酶1抗体Rat, Chicken, Pig, Cow, Horse, Sheep, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human LIM Kinase 1 around the phosphorylation site of Thr508.

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Predicted Molecular Weight: 73kDa.

磷酸化单丝氨酸蛋白激酶1抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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