磷酸化蛋白酶活化受体4抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化蛋白酶活化受体4抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

PAR4 is a member of a unique family of GPCRs, the proteinase-activated receptors (PARs), that are activated by proteolytic cleavage of the N-terminal domain of the receptor to reveal a tethered ligand. The PAR family consists of 4 receptors; PAR1 and PAR3 are activated by thrombin, and PAR2 and PAR4 are activated by several serine proteases (Macfarlane et al.磷酸化蛋白酶活化受体4抗体, 2001). PAR4 is expressed along with PAR1 on human platelets, and each plays an important role in thrombin-induced platelet aggregation (Holinstat et al., 2006). However, platelets from mice express PAR4 but not PAR1, and platelets from mice lacking PAR4 fail to aggregate in response to thrombin (Sambrano et al., 2001). Mice lacking PAR4 are protected from mesenteric arteriole thrombosis, indicating that PAR4 is a potential target for treatment of thrombosis in humans.

磷酸化蛋白酶活化受体4抗体Also known as:

PAR 4; Par4 induced by effectors of apoptosis; PAWR; PRKC Apoptosis WT1 Regulator; PRKC apoptosis WT1 regulator protein; Prostate apoptosis response 4 protein; Prostate apoptosis response protein 4; Prostate apoptosis response protein PAR 4; Proteinase-Activated Receptor 4; Transcriptional repressor Par-4-like protein PAWR; TRANSCRIPTIONAL REPRESSOR PAR4; WT1 Interacting Protein; protease-activated receptor 4; 2310001G03Rik.

Specificity:

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Rabbit Polyclonal IgG,磷酸化蛋白酶活化受体4抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, .

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磷酸化蛋白酶活化受体4抗体Immunogen: KLH conjugated Synthesised phosphopeptide derived from human PAR4 around the phosphorylation site of Thr163.

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Predicted Molecular Weight: 44kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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