磷酸化3磷酸肌醇依赖性蛋白激酶1

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化3磷酸肌醇依赖性蛋白激酶1  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt  磷酸化3磷酸肌醇依赖性蛋白激酶1 inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.

磷酸化3磷酸肌醇依赖性蛋白激酶1Also known as:

PDK1(Phospho-Ser241); PDPK1 (phospho S241); PDPK1(phospho-S241); 3 phosphoinositide dependent protein kinase 1; hPDK 1; hPDK1; MGC20087 MGC35290; PDK 1; PDPK 1; PDPK1; PkB kinase; PkB kinase like gene 1; PkB like 1; PkB like; PRO0461; PDPK1_HUMAN.

Specificity:

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Rabbit Polyclonal IgG,磷酸化3磷酸肌醇依赖性蛋白激酶1 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human PDK1 around the phosphorylation site of Ser241.

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磷酸化3磷酸肌醇依赖性蛋白激酶1Predicted Molecular Weight: 61kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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